Yep. Set up a board to bridge the vent. Put spacer blocks on the other three legs to make the bed level.

== since the vent is in the floor that does need support across the vent and a few inches on either side ... put a pillow at the desk for a while so you do not bump it in the dark ..........

So I want to rearrange my bedroom so that I can add a desk, but I measured and the leg of my bed is on top of part of my vent? There is no other way to rearrange so that I can add a desk. Does anyone have a solution to this? Thanks!