That is work best done by a professional in that field
Get a grip and clear the shed..
You can spray it, but you won't get every spider.
I need to clear out my shed because is it a complete mess. It's a about 8 feet wide and 12 feet long. There are holes in the back so I can't seal it off completely but the property behind mine is just an empty lot.
There are an immeasurable amount of large spiders and whatever else in there. Last time I went in there I ended up with 2 big lumps on my head. I just want to chuck a fume bomb in there to kill everything before I give it a clear out.