The slats are probably not precisely measured, and may not even be designed for that mattress.
If it bothers you, get a bunkee board or something.
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On my bed it is 3.5 inch apart, land of beds told me the max can only be 3 inch apart. They also said it could damage the mattress and void the warranty.
Is this a bunch of rubbish, why would the bed frame be that far apart if that was the case??